Journal article
Impact of 16S rRNA Single Nucleotide Polymorphisms on Mycoplasma genitalium Organism Load with Doxycycline Treatment
TP Chua, J Danielewski, K Bodiyabadu, CS Bradshaw, DA Machalek, SM Garland, EL Plummer, LA Vodstrcil, GL Murray
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2022
DOI: 10.1128/aac.00243-22
Abstract
Doxycycline targets the 16S rRNA and is widely used for the treatment of sexually transmitted infections. While it is not highly effective at eradicating Mycoplasma genitalium infections, it can reduce organism load. The aim of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in the 16S rRNA gene of M. genitalium and change in organism load. M. genitalium samples were collected from 56 men prior to commencing doxycycline and at a median of 13 of 14 doses. These were sequenced for the 16S rRNA, and the association between 16S rRNA SNPs and change in organism load was determined. 16S rRNA sequences were available for 52/56 (92.9%) M. genitalium-infec..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Department of Health and Human Services Victorian Medical Research Acceleration Fund (G.L.M., C.S.B., and S.M.G.), Australian Research Council Research Hub to Combat Antimicrobial Resistance (project identifier IH190100021; G.L.M. and C.S.B.), and National Health and Medical Research Council Investigator Grant APP1197951 (S.M.G.).